Many discoveries have been made recently concerning prehistoric agriculture in North America. Gayle Fritz's recent work has shown that the cushaw squash ( Cucurbita argyrosperma) was part of the native crop complex before 1000 A.D. in the eastern Woodlands. It had previously been considered a Southwestern/Mesoamerican domesticate brought to the midwest by the Spaniards.
See:
Fritz, Gayle J.
   1994   Precolumbian Cucurbita argyrosperma ssp. argyrosperma in the
     Eastern Woodlands of North America.  Economic Botany48(3):280-292.

The distinctive C. argyrosperma plant is depicted in Birger Figurine from Cahokia (left); remains of the same plant from Ozark Rockshelter in NW Arkansas, ca. 1450 A.D.

She is convinced that knotweed (Polygonum erectum) was also a prehistoric Midwestern crop, although it is not yet clear if this plant was fully domesticated.


S.E.M. image of a P. erectum achene from the Spiro Site, Oklahoma, ca. 800 B.P.